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Cytokine gene polymorphism in human disease: on-line databases

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Abstract

The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. Interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Many studies have examined the relationship between cytokine gene polymorphism, cytokine gene expression in vitro, and the susceptibility to and clinical severity of diseases. A review of the findings of these studies is presented. An on-line version featuring appropriate updates is accessible from the World Wide Web site, http://www.pam.bris.ac.uk/services/GAI/cytokine4.htm.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, University of Bristol, Homoeopathic Hospital Site, Cotham, BS6 6JU, Bristol, UK

    J Bidwell & L Keen

  2. University of Glasgow Department of Surgery, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow, G31 2ER, Scotland

    G Gallagher

  3. Division of Clinical Immunology and Rheumatology, Tinsley Harrison Tower, Room 429, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, 35294–0006, AL, USA

    R Kimberly

  4. Department of Rheumatology, Leiden University Medical Center, C4-R, P.O. Box 9600, Leiden, 2300, RC, The Netherlands

    T Huizinga

  5. Medical Unit, St. Bartholomew’s and the Royal London Hospital School of Medicine and Dentistry, Whitechapel, London, E1 1BB, UK

    MF McDermott

  6. Department of Neurology, University of California San Francisco, 513 Parnassus Ave., San Francisco, 94143–0435, CA, USA

    J Oksenberg

  7. Division of AIDS, HIV Immunology and Diagnostics Branch, National Center for Infectious Diseases, Centers for Disease Control, Mailstop A25, 1600 Clifton Road NE, Atlanta, 30333, GA, USA

    J McNicholl

  8. Steno Diabetes Center, Niels Steensensvej 2, Gentofte, DK-2820, Denmark

    F Pociot

  9. Institut für Humangenetik, Universitätsklinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    C Hardt

  10. Dipartimento Scienze Mediche, Via Solaroli 17, Növara, 28100, Italy

    S D’Alfonso

Authors
  1. J Bidwell
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  2. L Keen
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  3. G Gallagher
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  4. R Kimberly
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  5. T Huizinga
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  6. MF McDermott
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  7. J Oksenberg
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  8. J McNicholl
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  9. F Pociot
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  10. C Hardt
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  11. S D’Alfonso
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Bidwell, J., Keen, L., Gallagher, G. et al. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun 1, 3–19 (1999). https://doi.org/10.1038/sj.gene.6363645

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  • DOI: https://doi.org/10.1038/sj.gene.6363645

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