Abstract
Objective:
This study is to examine the relationship between dietary selenium intake and 24-h urinary selenium excretion in Japanese population samples participating in the INTERMAP Study.
Methods:
Using highly standardized methods, we assessed individual dietary selenium intake from four 24-h dietary recalls and measured urinary selenium excretion in two timed 24-h urine collections in 1145 Japanese participants (574 men and 571 women) ages 40–59 years in four areas of Japan.
Results:
The medians of dietary selenium intake were 177.5 μg/day in men and 139.8 μg/day in women; the medians of 24-h urinary selenium excretion were 127.9 μg/day in men and 109.4 μg/day in women, that is, urinary excretion was estimated to be 73% of dietary intake in men and 77% in women. Dietary selenium intake was significantly correlated with 24-h urinary selenium excretion (r=0.24 in men, r=0.18 in women; P<0.001). With dietary selenium intake and urinary selenium excretion expressed per kg of body weight, values were similar for men and women (dietary intake, 2.7 μg/kg body weight in men and 2.5 μg/kg body weight in women; urinary excretion, 2.0 μg/kg body weight in men and 2.0 μg/kg body weight in women).
Conclusion:
Dietary intake and 24-h urinary excretion of selenium are related in the Japanese adult population.
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Acknowledgements
We acknowledge the fine collaborative efforts of all INTERMAP staff. A comprehensive listing of colleagues from participating field centers, coordinating centers, Steering and Editorial, and Advisory Committees is given in a reference here (Stamler et al., 2003b). This study was partly supported by Grant-in-Aid for Scientific Research (A) (no. 090357003) and (C) (no. 13670394) from the Ministry of Education, Science, Sports and Culture, Japan, and by Grant 2-RO1-HL50490 from the US National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
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Contributors: SY: writing of the paper and data analysis; KM: writing of the paper, data analysis and data collection in Toyama center; KI: design, measurement and quality control of urinary selenium; KY: design and quality control of nutritional survey; HN: study design, principal investigator of Toyama center and writing of the paper; TS: design and quality control of urinary selenium; AO: study design and principal investigator of Aito Town center; KS: study design and principal investigator of Wakayama center; SS: study design and principal investigator of Sapporo center; HU: study design, principal investigator of INTERMAP Japan and writing of the paper; PE: study design; principal investigator of INTERMAP international study and writing of the paper, JS: study design, principal investigator of INTERMAP international study and writing of the paper.
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Yoneyama, S., Miura, K., Itai, K. et al. Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan. Eur J Clin Nutr 62, 1187–1193 (2008). https://doi.org/10.1038/sj.ejcn.1602842
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DOI: https://doi.org/10.1038/sj.ejcn.1602842
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