Skip to main content

Advertisement

SpringerLink
Log in

Comments on Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein: A possible explanation for contradictory in vivo and vitro results of interleukin-2 treatment in a rat model of colon carcinoma metastasis

  • Letter
  • Published:
Cancer Gene Therapy Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Tanji H, Yahata H, Hayamizu K, et al. Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein. Cancer Gene Ther. 2002;9:655–664.

    Article  CAS  Google Scholar 

  2. Braet F, Luo D, Spector I, Vermijlen D, Wisse E . Endothelial and pit cells. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz DA, eds. The Liver: Biology and Pathobiology, 4th edn. Philadelphia: Lippincott Williams & Wilkins; 2001:437–453.

    Google Scholar 

  3. Wisse E, Luo D, Vermijlen D, et al. On the function of pit cells, the liver-specific natural killer cells. Semin Liver Dis. 1997;17:265–286.

    Article  CAS  Google Scholar 

  4. Shiratori Y, Kanai F, Hikiba Y, et al. Gene therapy for hepatic micrometastasis of murine colon carcinoma. J Hepatol. 1998;28:886–895.

    Article  CAS  Google Scholar 

  5. Vanderkerken K, Bouwens L, Wisse E . Characterization of a phenotypically and functionally distinct subset of large granular lymphocytes (pit cells) in rat liver sinusoids. Hepatology. 1990;12:70–75.

    Article  CAS  Google Scholar 

  6. Luo D, Vanderkerken K, Chen MC, et al. Rat hepatic natural killer cells (pit cells) express mRNA and protein similar to in vitro interleukin-2 activated spleen natural killer cells. Cell Immunol. 2001;210:41–48.

    Article  CAS  Google Scholar 

  7. Vermijlen D, Luo D, Robaye B, et al. Pit cells (hepatic natural killer cells) of the rat induce apoptosis in colon carcinoma cells by the perforin/granzyme pathway. Hepatology. 1999;29:51–56.

    Article  CAS  Google Scholar 

  8. Bouwens L, Remels L, Baekeland M, et al. Large granular lymphocytes or “pit cells” from rat liver: isolation, ultrastructural characterization and natural killer activity. Eur J Immunol. 1987;17:37–42.

    Article  CAS  Google Scholar 

  9. Vanderkerken K, Bouwens L, De Neve W, et al. Origin and differentiation of hepatic natural killer cells (pit cells). Hepatology. 1993;18:919–925.

    Article  CAS  Google Scholar 

  10. Timmers M, Vermijlen D, Vekemans K, et al. Tracing DiO-labelled tumour cells in liver sections by confocal laser scanning microscopy. J Microsc. 2002;208:65–74.

    Article  CAS  Google Scholar 

  11. Rushfeldt C, Sveinbjornsson B, Seljelid R, et al. Early events of hepatic metastasis formation in mice: role of Kupffer and NK-cells in natural and interferon-gamma-stimulated defense. J Surg Res. 1999;82:209–215.

    Article  CAS  Google Scholar 

  12. Edmiston KH, Shoji Y, Mizoi T, et al. Role of nitric oxide and superoxide anion in elimination of low metastatic human colorectal carcinoma by unstimulated hepatic sinusoidal endothelial cells. Cancer Res. 1998;58:1524–1531.

    CAS  PubMed  Google Scholar 

  13. Wiltrout RH . Regulation and antimetastatic functions of liver-associated natural killer cells. Immunol Rev. 2000;174:63–76.

    Article  CAS  Google Scholar 

  14. Bouwens L, Marinelli A, Kuppen PJ, et al. Electron microscopic observations on the accumulation of large granular lymphocytes (pit cells) and Kupffer cells in the liver of rats treated with continuous infusion of interleukin-2. Hepatology. 1990;12:1365–1370.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Cell Biology and Histology, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussels, 1090, Belgium

    David Vermijlen, Maarten Timmers & Eddie Wisse

Authors
  1. David Vermijlen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maarten Timmers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eddie Wisse
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vermijlen, D., Timmers, M. & Wisse, E. Comments on Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein: A possible explanation for contradictory in vivo and vitro results of interleukin-2 treatment in a rat model of colon carcinoma metastasis. Cancer Gene Ther 10, 432–433 (2003). https://doi.org/10.1038/sj.cgt.7700582

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.cgt.7700582

  • Springer Nature America, Inc.

Search

Navigation