Skip to main content

Advertisement

Log in

Severe graft failure presumably due to phenytoin-induced hypersensitivity syndrome in two patients after bone marrow transplantation

  • Letter to the Editor
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

References

  1. Carroll MC, Yueng-Yue KA, Esterly NB, Drolet BA . Drug-induced hypersensitivity syndrome in pediatric patients. Pediatrics 2001; 108: 485–492.

    Article  CAS  PubMed  Google Scholar 

  2. Handoko KB, Souverein PC, van Staa TP, Meyboom RH, Leufkens HG, Egberts TC et al. Risk of aplastic anemia in patients using antiepileptic drugs. Epilepsia 2006; 47: 1232–1236.

    Article  PubMed  Google Scholar 

  3. Gogtay NJ, Bavdekar SB, Kshirsagar NA . Anticonvulsant hypersensitivity syndrome: a review. Expert Opin Drug Saf 2005; 4: 571–581.

    Article  PubMed  Google Scholar 

  4. Pichler WJ . Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139: 683–693.

    Article  CAS  PubMed  Google Scholar 

  5. Descamps V, Bouscarat F, Laglenne S, Aslangul E, Veber B, Descamps D et al. Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome. Br J Dermatol 1997; 137: 605–608.

    Article  CAS  PubMed  Google Scholar 

  6. Suzuki Y, Inagi R, Aono T, Yamanishi K, Shiohara T . Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998; 134: 1108–1112.

    Article  CAS  PubMed  Google Scholar 

  7. Shear NH, Spielberg SP . Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 1988; 82: 1826–1832.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gennis MA, Vemuri R, Burns EA, Hill JV, Miller MA, Spielberg SP . Familial occurrence of hypersensitivity to phenytoin. Am J Med 1991; 91: 631–634.

    Article  CAS  PubMed  Google Scholar 

  9. Gaedigk A, Spielberg SP, Grant DM . Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics 1994; 4: 142–153.

    Article  CAS  PubMed  Google Scholar 

  10. Beeler A, Engler O, Gerber BO, Pichler WJ . Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 2006; 117: 455–462.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B Maecker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maecker, B., Meissner, B., Bettoni da Cunha-Riehm, C. et al. Severe graft failure presumably due to phenytoin-induced hypersensitivity syndrome in two patients after bone marrow transplantation. Bone Marrow Transplant 41, 833–835 (2008). https://doi.org/10.1038/sj.bmt.1705985

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705985

  • Springer Nature Limited

Navigation