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Multiple myeloma patients receiving pre-emptive donor lymphocyte infusion after partial T-cell-depleted allogeneic stem cell transplantation show a long progression-free survival

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Abstract

The purpose of this study was to determine the role of pre-emptive donor lymphocyte infusion (pDLI) after partial T-cell-depleted allogeneic SCT in patients with multiple myeloma (MM). A cohort of 24 MM patients was treated with partial T-cell-depleted myeloablative SCT between December 1997 and April 2002. These patients were intended to receive pDLI after SCT. The overall response rate after SCT was 83% (20 of 24 patients) with 10 patients (42%) in complete remission (CR). Transplant-related mortality within 1 year after SCT was 29%. Thirteen patients (54%) received pDLI and four patients in partial remission reached CR. GVHD>grade I after pDLI developed in 4 out of 13 patients (30%). Four patients received therapeutic DLI, without preceding pDLI. Eleven patients (46%) are alive, with a median follow-up of 67 months (range, 48–100 months). Seven of these patients (29%) are in continuous CR (CCR), which was confirmed by a negative patient-specific IgH PCR in four patients. All seven patients in CCR received pDLI. Although myeloablative SCT in MM induces high toxicity, we show that the concept of T-cell depletion followed by pDLI is promising and needs to be investigated in a reduced-intensity conditioning setting.

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Authors and Affiliations

  1. Department of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    H Levenga, S Levison-Keating, A V Schattenberg, N Schaap & R A Raymakers

  2. Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    H Dolstra

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  1. H Levenga
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  2. S Levison-Keating
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  3. A V Schattenberg
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  4. H Dolstra
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  5. N Schaap
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  6. R A Raymakers
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Correspondence to H Levenga.

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Levenga, H., Levison-Keating, S., Schattenberg, A. et al. Multiple myeloma patients receiving pre-emptive donor lymphocyte infusion after partial T-cell-depleted allogeneic stem cell transplantation show a long progression-free survival. Bone Marrow Transplant 40, 355–359 (2007). https://doi.org/10.1038/sj.bmt.1705742

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  • DOI: https://doi.org/10.1038/sj.bmt.1705742

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