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Umbilical cord blood stem cell transplantation from unrelated HLA-matched donor in an infant with severe congenital neutropenia

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Summary:

We report here a 6-month-old boy with severe congenital neutropenia (SCN) successfully treated by cord blood stem cell transplantation (CBSCT) from an unrelated donor. He had recurrent life-threatening respiratory infection due to severe neutropenia that was refractory to recombinant human granulocyte colony-stimulating factor (rhG-CSF). Because he had no HLA-matched sibling and no time to wait for unrelated donor, he received HLA-matched unrelated CBSCT as determined by DNA typing. A total of 6.4 × 107 CB nucleated cells/kg was infused after conditioning with busulfan/horse antihuman thymocyte serum/cyclophosphamide. No GVHD developed under the treatment with cyclosporin A and methyl prednisolone. The neutrophil count reached 0.5 × 109/l on day 14, reticulocyte 1% on day 13 and platelet count over 50 × 109/l on day 31. We conclude that unrelated CBSCT can be an indication for some cases of SCN, who have recurrent life-threatening infections and are refractory to rhG-CSF, and have no HLA-matched sibling.

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Authors and Affiliations

  1. Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan

    E Mino, R Kobayashi, M Yoshida, Y Suzuki, M Yamada & K Kobayashi

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  1. E Mino
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  2. R Kobayashi
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  3. M Yoshida
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  4. Y Suzuki
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  5. M Yamada
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  6. K Kobayashi
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Correspondence to E Mino.

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Mino, E., Kobayashi, R., Yoshida, M. et al. Umbilical cord blood stem cell transplantation from unrelated HLA-matched donor in an infant with severe congenital neutropenia. Bone Marrow Transplant 33, 969–971 (2004). https://doi.org/10.1038/sj.bmt.1704439

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  • DOI: https://doi.org/10.1038/sj.bmt.1704439

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