Skip to main content
Log in

Technical Report

Performance of a hybrid central venous catheter utilized for both peripheral blood stem cell harvest and transplant support of patients undergoing autologous peripheral blood stem cell transplantation

  • Original Article
  • Published:
Bone Marrow Transplantation Submit manuscript

Abstract

Patients undergoing autologous peripheral blood stem cell transplantation (PBSC) frequently require the sequential insertion of two central venous catheters, one for leukapheresis and one for transplant support. Hybrid catheters suitable for leukapheresis and long-term use have been increasingly used, but there is limited information regarding their performance and complication rate. The purpose of this study was to determine the performance of the Pheres-Flow hybrid catheter when utilized for both leukapheresis and transplant support, with particular emphasis on the incidence of infectious and occlusive complications. We prospectively analyzed the performance of 92 catheters in 82 consecutive patients who underwent autologous peripheral blood stem cell (PBSC) transplantation. Occlusion was the most frequent complication of this catheter with 29% of the patients experiencing difficulty drawing blood or infusing fluids. Infection was another frequent complication. Twenty-two percent of patients developed catheter-related bloodstream infections and 15 catheters had to be removed because of proven or suspected infection that did not respond to antibiotic therapy. Nevertheless, 77% of patients were able to complete leukapheresis and transplant support with only one catheter. We conclude that the utilization of the Pheres-Flow catheter for both leukapheresis and transplant support is feasible, but that new strategies need to be developed to decrease the incidence of occlusive and infectious complications of hybrid catheters.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Lazarus HM, Trehan S, Miler R et al. Multi-purpose silastic dual-lumen central venous catheter for both collection and transplantation of hematopoietic progenitor cells Bone Marrow Transplant 2000 25: 779 785

    Article  CAS  Google Scholar 

  2. Meisenberg BR, Callaghan M, Sloan C et al. Complications associated with central venous catheters used for the collection of peripheral blood progenitor cells to support high dose chemotherapy and autologous stem cell rescue Support Care Cancer 1997 5: 223 227

    Article  CAS  Google Scholar 

  3. Cera SM, Carpenter T, Frenette G, White RL . The Neostar catheter: improved venous access for high dose chemotherapy and pheresis J Clin Oncol 2001 20 (Suppl. 2): 5b (Abstr. 1766)

    Google Scholar 

  4. Pearson ML . Guideline for prevention of intravascular-device-related infections Infect Control Hosp Epidemiol 1996 17: 438 473

    Article  CAS  Google Scholar 

  5. Sherertz RJ . Surveillance for infections associated with vascular catheters Infect Control Hosp Epidemiol 1996 17: 746 752

    Article  CAS  Google Scholar 

  6. Freytes CO . Indications and complications of intravenous devices for chemotherapy Curr Opin Oncol 2000 12: 303 1307

    Article  CAS  Google Scholar 

  7. Eastridge BJ, Lefor AT . Complications of indwelling venous access devices in cancer patients J Clin Oncol 1995 13: 233 238

    Article  CAS  Google Scholar 

  8. Freytes CO . Vascular access problems revisited: the Multinational Association of Supportive Care in Cancer (MASCC) experience Support Care Cancer 1998 6: 13 19

    Article  CAS  Google Scholar 

  9. Edmond MB, Ober JF, Weinbaum DL et al. Vancomycin-resistant Enterococcus faecium bacteremia: risk factors for infection Clin Infect Dis 1995 20: 1126 1133

    Article  CAS  Google Scholar 

  10. Keung YK, Watkins K, Chen SC et al. Increased incidence of central venous catheter-related infections in bone marrow transplant patients Am J Clin Oncol 1995 18: 469 474

    Article  CAS  Google Scholar 

  11. Moosa HH, Julian TB, Rosenfeld CS et al. Complications of indwelling central venous catheters in bone marrow transplant recipients Surg Gynecol Obstet 1991 172: 275 279

    CAS  Google Scholar 

  12. Howell PB, Walters PE, Donnowitz GR et al. Risk factors for infection of adult patients with cancer who have tunneled central venous catheters Cancer 1995 75: 1367 1375

    Article  CAS  Google Scholar 

  13. Early TF, Gregory RT, Wheeler JR et al. Increased infection rate in double-lumen versus single lumen Hickman catheters in cancer patients South Med J 1990 83: 34 36

    Article  CAS  Google Scholar 

  14. Haire WD, Lieberman RP, Lund GB et al. Thrombotic complications of silicone rubber catheters during autologous marrow and peripheral stem cell transplantation: prospective comparison of Hickman and Groshong catheters Bone Marrow Transplant 1991 7: 57 59

    CAS  Google Scholar 

  15. Conlan MG, Haire WD, Lieberman RP et al. Catheter-related thrombosis in patients with refractory lymphoma undergoing autologous stem cell transplantation Bone Marrow Transplant 1991 7: 235 240

    CAS  Google Scholar 

Download references

Acknowledgements

We are indebted to Bibi Cates for expert secretarial assistance and the housestaff and nurses of the University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital for excellent patient care.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Restrepo, A., Devore, P., Encarnación, C. et al. Performance of a hybrid central venous catheter utilized for both peripheral blood stem cell harvest and transplant support of patients undergoing autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 30, 389–395 (2002). https://doi.org/10.1038/sj.bmt.1703647

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703647

  • Springer Nature Limited

Keywords

This article is cited by

Navigation