Abstract
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
Bone Marrow Transplantation (2001) 28, 1157–1160.
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Acknowledgements
Mohamad Mohty was supported by a grant from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).
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Mohty, M., Faucher, C., Gaugler, B. et al. Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report. Bone Marrow Transplant 28, 1157–1160 (2001). https://doi.org/10.1038/sj.bmt.1703308
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DOI: https://doi.org/10.1038/sj.bmt.1703308
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