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Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenström's macroglobulinemia with severe pancytopenia

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Abstract

We report a 62-year-old male who underwent non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) because of his life-threatening severe pancytopenia due to refractory Waldenström's macroglobulinemia. This therapy was performed safely and he made a marked recovery from his cytopenia that had not been improved with any other therapy. Bone marrow aspirates showed post-transplant mixed chimerism during engraftment, and became completely donor-derived after a series of GVHD symptoms, without subsequent donor lymphocyte infusion. Our results suggest that non-myeloablative allogeneic PBSCT could be a good alternative for patients suffering from multi-drug resistant Waldenström's macroglobulinemia. Bone Marrow Transplantation (2001) 28, 609–611.

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Acknowledgements

We would like to thank Masaharu Kouno, Toshitsugu Negoro and Takahiro Yonemoto for their skillful technical assistance.

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  1. Department of Internal Medicine, Rinku General Medical Center, Izumisano, Osaka, Japan

    T Ueda, K Hatanaka, S Kosugi, B-I Kishino & T Tamaki

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  1. T Ueda
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  2. K Hatanaka
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  3. S Kosugi
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  4. B-I Kishino
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  5. T Tamaki
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Ueda, T., Hatanaka, K., Kosugi, S. et al. Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenström's macroglobulinemia with severe pancytopenia. Bone Marrow Transplant 28, 609–611 (2001). https://doi.org/10.1038/sj.bmt.1703190

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  • DOI: https://doi.org/10.1038/sj.bmt.1703190

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