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Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

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Abstract

We report the case of a 46-year-old male who developed dermatomyositis and a sarcoid-like reaction in association with testicular relapse of multiple myeloma. The myositis progressed despite chemotherapy directed at the underlying malignant disorder and immunosuppressive treatment. There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction. This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies. Bone Marrow Transplantation (2001) 27, 1215–1217.

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References

  1. Baron F, Ribbens C, Kaye O et al. Effective treatment of Jo-1-associated polymyositis with T-cell-depleted autologous peripheral blood stem cell transplantation Br J Haematol 2000 110: 339–342

    Article  CAS  Google Scholar 

  2. Tyndall A, Fassas A, Passweg J et al. Autologous haematopoietic stem cell transplants for autoimmune disease – feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease Bone Marrow Transplant 1999 24: 729–734

    Article  CAS  Google Scholar 

  3. Bohan A, Peter JB . Polymyositis and dermatomyositis New Engl J Med 1975 292: 403–407

    Article  CAS  Google Scholar 

  4. Maoz CR, Langevitz P, Livneh A et al. High incidence of malignancies in patients with dermatomyositis and polymyositis: an 11-year analysis Semin Arthritis Rheum 1998 27: 319–324

    Article  CAS  Google Scholar 

  5. Brincker H . The sarcoidosis-lymphoma syndrome Br J Cancer 1986 54: 467–473

    Article  CAS  Google Scholar 

  6. Beck P . Myelomatosis presenting as dermatomyositis Br Med J 1968 1: 747–748

    Article  CAS  Google Scholar 

  7. Caron P, Lassoued S, Thibaut I et al. Thyroid plasmacytoma with dermatomyositis and palmar fasciitis J Rheumatol 1989 16: 997–999

    CAS  PubMed  Google Scholar 

  8. Brincker H . Sarcoid reactions in malignant tumours Cancer Treat Rev 1986 13: 147–156

    Article  CAS  Google Scholar 

  9. Lepidi H, Frances V, Figarella-Branger D et al. Local expression of cytokines in idiopathic inflammatory myopathies Neuropathol Appl Neurobiol 1998 24: 73–79

    Article  CAS  Google Scholar 

  10. Osterborg A, Yi Q, Bergenbrant S et al. Idiotype-specific T cells in multiple myeloma stage I: an evaluation by four different functional tests Br J Haematol 1995 89: 110–116

    Article  CAS  Google Scholar 

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Chakraverty, R., Rabin, N., Peggs, K. et al. Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 27, 1215–1217 (2001). https://doi.org/10.1038/sj.bmt.1703048

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