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Re-mobilization of peripheral blood progenitor cells within a short time interval fails to achieve effective progenitor cell yields

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Abstract

We report the case of a healthy donor who was mobilized for the purpose of performing an unrelated donor transplantation with subcutaneous injections of rhG-CSF. Because of accidental loss of progenitors, 3 days after completing the first collection, the donor was mobilized again with rhG-CSF, and progenitors were collected. While a similar increase in the pre-apheresis leukocyte count was observed in both procedures, fewer mononuclear cells were mobilized during the second rhG-CSF course, resulting in a poor CD34+ yield. These data suggest that an 8-day interval between commencement of rhG-CSF mobilizations is insufficient to predict an efficient collection of hematopoietic progenitors to ensure engraftment after bone marrow transplantation. Bone Marrow Transplantation (2000) 26, 351–352.

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Acknowledgements

MLL is a Fundación Séneca Fellow.

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Authors and Affiliations

  1. Unit of Hematology and Clinical Oncology, University General Hospital and School of Medicine, Murcia, Spain

    C Vallejo, ML Lozano, F Ortuño, JM Moraleda & V Vicente

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  1. C Vallejo
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  2. ML Lozano
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  3. F Ortuño
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  4. JM Moraleda
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  5. V Vicente
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Vallejo, C., Lozano, M., Ortuño, F. et al. Re-mobilization of peripheral blood progenitor cells within a short time interval fails to achieve effective progenitor cell yields. Bone Marrow Transplant 26, 351–352 (2000). https://doi.org/10.1038/sj.bmt.1702515

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  • DOI: https://doi.org/10.1038/sj.bmt.1702515

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