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Aspergillus tracheobronchitis after allogeneic bone marrow transplantation

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Abstract

We describe a patient who developed Aspergillus tracheobronchitis after BMT. She complained of progressive dyspnea on day +165 and her respiratory function deteriorated rapidly. Although neither early chest X-rays nor CT scans were negative, bronchoscopy revealed formation of a pseudomembrane around the bronchial walls. Based upon pathological and microbiological examinations, she was diagnosed as having invasive Aspergillus tracheobronchitis. Retrospectively analyzed, the Aspergillus circulating antigen detection tests became positive before clinical symptoms developed, and may be beneficial for early diagnosis of Aspergillus tracheobronchitis. This form of aspergillosis should be regarded as one of the serious complications after BMT.

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Authors and Affiliations

  1. The Department of Hematology and Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    U Machida, M Kami, Y Kanda, N Takeda, Y Tanaka, S Chiba, H Honda & H Hirai

  2. The Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    K Takeuchi & C Kakiuchi

  3. The Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    M Akahane

  4. The Department of Traumatology and Critical Care, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    I Yamaguchi

Authors
  1. U Machida
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  2. M Kami
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  3. Y Kanda
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  4. K Takeuchi
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  5. M Akahane
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  6. I Yamaguchi
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  7. C Kakiuchi
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  8. N Takeda
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  9. Y Tanaka
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  10. S Chiba
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  11. H Honda
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  12. H Hirai
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Machida, U., Kami, M., Kanda, Y. et al. Aspergillus tracheobronchitis after allogeneic bone marrow transplantation. Bone Marrow Transplant 24, 1145–1149 (1999). https://doi.org/10.1038/sj.bmt.1702030

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  • DOI: https://doi.org/10.1038/sj.bmt.1702030

  • Springer Nature Limited

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