Abstract
Fulminant hepatic failure due to adenovirus infection is a rare complication following stem cell transplantation. We report this complication in an unrelated bone marrow transplant recipient 30 weeks post-transplant. Treatment with intravenous ribavirin was started within 36 h of admission, but he succumbed to unusually fulminant hepatic failure. Adenovirus type 2 was isolated from stool surveillance samples and from post-mortem liver samples. Adenovirus DNA was detected by PCR in blood and sputum samples at admission and was identified in post-mortem liver tissue by electron microscopy. Implications of the failure of ribavirin therapy are discussed.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chakrabarti, S., Collingham, K., Fegan, C. et al. Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant 23, 1209–1211 (1999). https://doi.org/10.1038/sj.bmt.1701788
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701788
- Springer Nature Limited
Keywords
This article is cited by
-
Co-infection with human polyomavirus BK enhances gene expression and replication of human adenovirus
Archives of Virology (2018)
-
Fulminant hepatitis due to human adenovirus
Infection (2014)
-
Diagnosis and treatment of viral diseases in recipients of allogeneic hematopoietic stem cell transplantation
Journal of Hematology & Oncology (2013)
-
Disseminated Adenovirus Disease in Immunocompromised Patient Successfully Treated with Oral Ribavirin: A Case Report
Archivum Immunologiae et Therapiae Experimentalis (2011)