Skip to main content

Advertisement

SpringerLink
Log in

Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD)

  • Case Report
  • Published:
Bone Marrow Transplantation Submit manuscript

Abstract

We describe an allogeneic bone marrow (BM) recipient who developed aggressive, metastasizing squamous cell cancer (SCC) of the skin, and discuss possible risk factors in the development of this secondary solid tumor. The patient had been treated with cyclosporine (CsA), methyl-prednisolone and thalidomide for 3 years because of extensive de novo chronic cutaneous GVHD occurring 1 year after BMT. Ten years after BMT a locally invasive and metastasizing SCC occurred on the patient’s neck, and diagnosis was confirmed by H&E histopathology and cytokeratin-immunohistochemistry. Analysis of genomic DNA did not reveal p53 mutations nor were HPV sequences detectable. Risk factors included conditioning for BMT with total body irradiation (TBI) and cyclophosphamide (Cy), immunosuppressive treatment for GVHD, and extensive exposure to UV radiation before and after BMT. Despite surgery and adjuvant chemotherapy with 5-fluorouracil (5-FU) the patient died 1 year after the diagnosis of SCC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Division of Immunology, Department of Dermatology, Allergy and Infectious Diseases, University of Vienna Medical School, Vienna, Austria

    B Gmeinhart, R Kirnbauer & B Volc-Platzer

  2. 2nd Department of Internal Medicine , Donauspital, Vienna, Austria

    W Hinterberger

  3. Department of Internal Medicine I, Bone Marrow Transplantation Unit, University of Vienna Medical School, Vienna, Austria

    HT Greinix, W Rabitsch & E Reiter

Authors
  1. B Gmeinhart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W Hinterberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. HT Greinix
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W Rabitsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R Kirnbauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E Reiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B Volc-Platzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gmeinhart, B., Hinterberger, W., Greinix, H. et al. Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD). Bone Marrow Transplant 23, 1197–1199 (1999). https://doi.org/10.1038/sj.bmt.1701772

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1701772

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation