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Myasthenia gravis and polymyositis as manifestations of chronic graft-versus-host-disease

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Abstract

Myasthenia gravis and polymyositis are each a rare manifestation of immune dysregulation in chronic graft-versus-host disease (cGVHD). We report a 4-year-old boy with idiopathic acquired aplastic anemia who developed myasthenia gravis 22 months and polymyositis 69 months after an allogeneic BMT (5/6 matched, MLC-nonreactive). The occurrence of both syndromes in one patient is unique. Autoimmune dysfunction may be associated with the development of cGVHD as demonstrated by the high incidence of prior aplastic anemia in BMT patients presenting with myasthenia gravis and polymyositis. Recognition of these neurologic manifestations is important in the diagnosis and treatment of cGVHD.

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Authors and Affiliations

  1. Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada

    S Tse

  2. Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, Canada

    EF Saunders

  3. Department of Rheumatology, The Hospital for Sick Children, Toronto, Canada

    E Silverman

  4. Department of Neurology, The Hospital for Sick Children, Toronto, Canada

    J Vajsar & B Meaney

  5. Department of Pathology, The Hospital for Sick Children, Toronto, Canada

    L Becker

Authors
  1. S Tse
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  2. EF Saunders
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  3. E Silverman
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  4. J Vajsar
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  5. L Becker
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  6. B Meaney
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Tse, S., Saunders, E., Silverman, E. et al. Myasthenia gravis and polymyositis as manifestations of chronic graft-versus-host-disease. Bone Marrow Transplant 23, 397–399 (1999). https://doi.org/10.1038/sj.bmt.1701575

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  • DOI: https://doi.org/10.1038/sj.bmt.1701575

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