Abstract
A 2.5-year-old girl with neurogenic Gaucher’s disease was transplanted with donor bone marrow from her HLA-compatible 12-year-old brother whose marrow was harvested 30 min post-mortem, after he suffered a severe head and neck injury. The marrow was stored in liquid nitrogen for 30 days prior to infusion. The post-transplantation period was uneventful with good engraftment and no signs of graft-versus-host disease. Currently, 6 months post-allogeneic bone marrow transplantation (alloBMT), analysis of both bone marrow and blood samples by PCR documented only cells of donor origin. This case demonstrates the feasibility of cadaveric marrow as a source of donor cells. To our knowledge, this patient is the only survivor of alloBMT from a cadaveric donor.
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Kapelushnik, J., Aker, M., Pugatsch, T. et al. Bone marrow transplantation from a cadaveric donor. Bone Marrow Transplant 21, 857–858 (1998). https://doi.org/10.1038/sj.bmt.1701165
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DOI: https://doi.org/10.1038/sj.bmt.1701165
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