Abstract
Highly fluorescent reticulocyte (HFR) counts were evaluated in 13 consecutive patients affected by hematological malignancies and submitted to autologous selected CD34+ peripheral blood progenitor cell (PBPC) transplantation. Results were compared with a historical group of patients comparable for age, disease and conditioning regimen submitted to unfractionated PBPC transplantation. HFR counts of the CD34+ group declined to an undetectable level from day +4 to day +10 when they became detectable and reached 5% of total reticulocyte count by day +12. In the historical group, the nadir was identical but the recovery was faster (day +9). Total reticulocyte count >1% was achieved at days +17 and +11, respectively. The absolute neutrophil count (ANC) recovery was identical in both groups, achieving a value >0.5 × 109/l at day +13 after reinfusion. Hence, in the historical group, HFR count gave advance notice of complete and stable hemopoietic engraftment while in the CD34+ group HFR and ANC count showed almost simultaneous recovery.
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Sica, S., Salutari, P., Laurenti, L. et al. Highly fluorescent reticulocytes after CD34+ peripheral blood progenitor cell transplantation. Bone Marrow Transplant 21, 361–364 (1998). https://doi.org/10.1038/sj.bmt.1701098
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DOI: https://doi.org/10.1038/sj.bmt.1701098
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