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Intermediate-dose busulfan and cyclophosphamide as a conditioning regimen for bone marrow transplantation in a case of Fanconi anemia in myelodysplastic transformation

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Abstract

We report an 11-year old female with myelodysplastic (refractory anemia with excess of blasts) presentation of Fanconi anemia. After failure of initial chemotherapy with low doses of 6-mercaptopurine and prednisolone she underwent allogeneic bone marrow transplantation (BMT) from her HLA-matched sibling. Busulfan 8 mg/kg and cyclophosphamide 40 mg/kg were used as conditioning. The post-transplant course was uneventful with fast trilineage engraftment and mild cutaneous acute GVHD. She is alive 17 months after BMT with full hematological reconstitution without evidence of MDS.

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Authors and Affiliations

  1. Bone Marrow Transplantation Department, Research Institute for Pediatric Hematology of Russian Federation, Moscow, Russia

    AA Maschan, OI Kryzanovskii, MI Yourlova, EV Skorobogatova, ED Pashanov, YE Potapova, LA Timonova, NY Bogatcheva, EV Samochatova & AG Roumjantzev

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  1. AA Maschan
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  2. OI Kryzanovskii
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  3. MI Yourlova
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  4. EV Skorobogatova
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  5. ED Pashanov
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  6. YE Potapova
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  7. LA Timonova
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  8. NY Bogatcheva
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  9. EV Samochatova
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  10. AG Roumjantzev
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Maschan, A., Kryzanovskii, O., Yourlova, M. et al. Intermediate-dose busulfan and cyclophosphamide as a conditioning regimen for bone marrow transplantation in a case of Fanconi anemia in myelodysplastic transformation. Bone Marrow Transplant 19, 385–387 (1997). https://doi.org/10.1038/sj.bmt.1700662

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  • DOI: https://doi.org/10.1038/sj.bmt.1700662

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