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Integrated lifestyle factors mitigate depression risk across varied genetic susceptibility

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A large-scale prospective cohort study with 287,282 participants revealed that the integration of multiple healthy lifestyle factors (a favorable lifestyle) was associated with a lower risk of depression. Categorizing participants on the basis of their polygenic risk scores for depression demonstrated that the effect of this favorable lifestyle persisted even among participants with high genetic susceptibility.

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Fig. 1: Depression risk according to lifestyle factors and underlying mechanisms.

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This is a summary of: Zhao, Y. et al. The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00120-1 (2023).

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Integrated lifestyle factors mitigate depression risk across varied genetic susceptibility. Nat. Mental Health 1, 709–710 (2023). https://doi.org/10.1038/s44220-023-00127-8

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