By integrating neuroimaging and multi-omics data, we established links between individual genetic variations and macro- to microscale brain circuit dysfunctions, specifically in corticocortical and corticostriatal circuits, that contribute to the diverse clinical manifestations of schizophrenia. These findings advance our understanding of the disease’s heterogeneity and offer potential treatment insights.
This is a preview of subscription content, log in via an institution to check access.
References
McCutcheon, R. A. et al. Schizophrenia: an overview. JAMA Psychiatry 77, 201 (2020). A review article that presents an overview of schizophrenia, including its lifetime prevalence.
Reed, G. M. et al. Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders. World Psychiatry 18, 3–19 (2019). This paper reports that subtypes of schizophrenia have been removed from the ICD-11.
Smeland, O. B. et al. The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nat. Rev. Neurol. 16, 366–379 (2020). A review article presenting polygenic discoveries of schizophrenia that might be instrumental in addressing clinical heterogeneity.
Chand, G. B. et al. Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning. Brain 143, 1027–1038 (2020). This paper reports two subtypes of schizophrenia based on brain imaging data.
Li, A. et al. A neuroimaging biomarker for striatal dysfunction in schizophrenia. Nat. Med. 26, 558–565 (2020). This paper reports that striatum-to-cortex functional dysconnectivity can be used to construct a neuroimaging biomarker of schizophrenia.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Wang, M. et al. Neuroimaging and multiomics reveal crossscale circuit abnormalities in schizophrenia. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00110-3 (2023).
Rights and permissions
About this article
Cite this article
Bridging the cross-scale heterogeneity of schizophrenia. Nat. Mental Health 1, 611–612 (2023). https://doi.org/10.1038/s44220-023-00117-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44220-023-00117-w
- Springer Nature America, Inc.