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Time to synergize mental health with brain health

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This Comment highlights the intertwined nature of mental and brain health and disease. Common genetic, environmental and lifestyle factors contribute to psychiatric and neurological disorders, which partially share neurocognitive and pathophysiological mechanisms. A call for a more dimensional, interdisciplinary approach can accelerate the development of robust approaches to research, prevention and intervention.

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Fig. 1: Common and interconnected levels of analysis across mental health and brain health fields and diseases.

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Acknowledgements

This work was supported by grants from Takeda CW2680521; ANID/FONDECYT Regular (1210195, 1210176 and 1220995); ANID/FONDAP/15150012; and ReDLat: the National Institutes of Health and the Fogarty International Center (FIC), National Institutes of Aging (R01 AG057234), Alzheimer’s Association (SG-20-725707), Rainwater Charitable Foundation; and Global Brain Health Institute (all grants to A.I.). The contents of this publication are solely the authors’ responsibility and do not represent the official views of these institutions.

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Authors and Affiliations

  1. Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), California, CA, USA

    Agustin Ibanez

  2. Trinity College Dublin (TCD), Dublin, Ireland

    Agustin Ibanez

  3. Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile

    Agustin Ibanez

  4. Department of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    Eduardo R. Zimmer

  5. Graduate Program in Biological Sciences: Biochemistry (PPGBioq) and Pharmacology and Therapeutics (PPGFT), UFRGS, Porto Alegre, Brazil

    Eduardo R. Zimmer

  6. McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada

    Eduardo R. Zimmer

  7. Brain Institute of Rio Grande do Sul, Pontíficia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

    Eduardo R. Zimmer

Authors
  1. Agustin Ibanez
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  2. Eduardo R. Zimmer
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Correspondence to Agustin Ibanez.

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The authors declare no competing interests.

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Nature Mental Health thanks Joëlle Rüegg and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Ibanez, A., Zimmer, E.R. Time to synergize mental health with brain health. Nat. Mental Health 1, 441–443 (2023). https://doi.org/10.1038/s44220-023-00086-0

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