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Occular lymphatics

An immunological window to the brain

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From Nature Cardiovascular Research

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The eye and the brain are both recognized as immune-privileged sites. Research now indicates that responses in the eye mirror those in the central nervous system (CNS), offering major implications for the treatment of CNS cancers and infections.

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Fig. 1: Anatomical and functional disparities in antigen drainage from the anterior chamber and vitreous of the eye.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    James T. Walsh

  2. Brain Immunology and Glia (BIG) Center, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    James T. Walsh & Jonathan Kipnis

  3. Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    Jonathan Kipnis

Authors
  1. James T. Walsh
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  2. Jonathan Kipnis
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Corresponding authors

Correspondence to James T. Walsh or Jonathan Kipnis.

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Competing interests

J.K. is a co-founder of Rho Bio. J.T.W. declares no competing interests.

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Walsh, J.T., Kipnis, J. An immunological window to the brain. Nat Cardiovasc Res 3, 405–406 (2024). https://doi.org/10.1038/s44161-024-00457-5

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