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Finding the right balance on the challenging path to clinical translation of anti-inflammatory therapies for ischemic heart disease

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From Nature Cardiovascular Research

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Although anti-inflammatory drugs have shown promising results in preclinical cardiovascular research, they have yielded little benefit in clinical trials. Before we can expect positive outcomes, we need to find ways of stratifying patients based on their infectious, inflammatory and autoimmune profile, and identify the right time of treatment.

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Fig. 1: Finding the right balance.

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Acknowledgements

The thoughts presented in this Comment have been refined through many conversations with like-minded fellow cardioimmunologists. In particular, I would like to acknowledge G. Campos Ramos, M. Kallikourdis and P. Alcaide. This work was supported by funding from the Austrian Science Fund (P36588-B), the British Heart Foundation (P84083), and the Leducq Foundation.

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Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College London, London, UK

    Susanne Sattler

  2. Department of Pharmacology, Otto-Loewi Research Center, Medical University of Graz, Graz, Austria

    Susanne Sattler

  3. Department of Cardiology, LKH Univ. Klinikum Graz, Medical University of Graz, Graz, Austria

    Susanne Sattler

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  1. Susanne Sattler
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Correspondence to Susanne Sattler.

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Sattler, S. Finding the right balance on the challenging path to clinical translation of anti-inflammatory therapies for ischemic heart disease. Nat Cardiovasc Res 3, 245–247 (2024). https://doi.org/10.1038/s44161-024-00440-0

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