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Cardiac renewal

Cellular crosstalk to regenerate the injured heart

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From Nature Cardiovascular Research

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The cellular microenvironment and interplay between cell types are essential for cardiac renewal. Combined single-cell and single-nucleus sequencing, spatial transcriptomics and loss-of-function experiments in constitutively YAP-expressing infarcted hearts reveal a cellular triad and complement signaling that evoke renewal of heart muscle.

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Fig. 1: YAP activation in the injured adult heart establishes a cellular niche to facilitate heart muscle renewal.

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Authors and Affiliations

  1. Institute of Developmental & Regenerative Medicine, University of Oxford, Oxford, UK

    Paul R. Riley

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  1. Paul R. Riley
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Correspondence to Paul R. Riley.

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The author declares no competing interests.

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Riley, P.R. Cellular crosstalk to regenerate the injured heart. Nat Cardiovasc Res 3, 248–250 (2024). https://doi.org/10.1038/s44161-024-00426-y

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