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Visualizing inflammatory monocytes and macrophages in the human heart

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From Nature Cardiovascular Research

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Inflammatory monocytes and macrophages in the heart express C-C chemokine receptor 2 (CCR2) on their cell surface and contribute to heart failure pathogenesis. This study established the feasibility of imaging CCR2+ cells by positron emission tomography in patients with myocardial infarction.

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Fig. 1: CCR2 imaging in control individuals and patients with myocardial infarction.

References

  1. Bajpai, G. et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat. Med. 24, 1234–1235 (2018). This paper demonstrates the relevance of CCR2+ monocytes and macrophages in the human heart.

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Lavine, K. J. et al. CCR2 imaging in human ST-segment elevation myocardial infarction. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00335-6 (2023).

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Visualizing inflammatory monocytes and macrophages in the human heart. Nat Cardiovasc Res 2, 869–870 (2023). https://doi.org/10.1038/s44161-023-00345-4

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