Targeting the Notch ligand DLL4 in adult liver vessels induced transcriptional states associated with endothelial cell (EC) proliferation and sprouting. However, genetic and pharmacological inhibition of these angiogenic cell states did not prevent an abnormal vasculature and pathology in the liver, suggesting that transcriptional states do not always inform on the vascular phenotype and related pathophysiology.
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References
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This is a summary of: Fernández-Chacón, M. et al. Incongruence between transcriptional and vascular pathophysiological cell states. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-023-00272-4 (2023).
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Transcriptional states do not always predict vascular function and pathology. Nat Cardiovasc Res 2, 498–499 (2023). https://doi.org/10.1038/s44161-023-00279-x
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DOI: https://doi.org/10.1038/s44161-023-00279-x
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