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Statin therapy enhances vascular health through epigenetic mechanisms

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Our study demonstrates that statins improve endothelial function and vascular health by inhibiting the epigenetic activation of the YAP–SOX9 signaling axis and subsequently preventing endothelial-to-mesenchymal transition in conditions associated with an increased risk of cardiovascular disease, such as type 2 diabetes.

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Fig. 1: Epigenetic alterations induced by simvastatin treatment in iPSC-ECs.

References

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This is a summary of: Liu, C. et al. Statins improve endothelial function via suppression of epigenetic-driven EndMT. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-023-00267-1 (2023).

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Statin therapy enhances vascular health through epigenetic mechanisms. Nat Cardiovasc Res 2, 502–503 (2023). https://doi.org/10.1038/s44161-023-00274-2

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