Endothelial cell–cell contacts in blood vessels constitute a barrier to the flux of molecules and cells from blood to tissues. We identified the tyrosine-protein kinase Yes as the principal regulator of collective endothelial cell migration and vascular barrier dynamics, a finding that opens avenues for future therapeutic development.
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This is a summary of: Jin, Y. et al. Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00172-z (2022).
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Tyrosine-protein kinase Yes is essential in vascular barrier dynamics. Nat Cardiovasc Res 1, 1136–1137 (2022). https://doi.org/10.1038/s44161-022-00195-6
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DOI: https://doi.org/10.1038/s44161-022-00195-6
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