Myocardial ischemia–reperfusion injury (MIRI) substantially contributes to the morbidity associated with ischemic heart disease. Timed administration of digoxin decreased the susceptibility of mouse cardiomyocytes to MIRI; digoxin acted by promoting proteasomal degradation of the nuclear receptor REV-ERBα, a key component of the molecular circadian clock.
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References
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This is a summary of: Vinod, M. et al. Timed use of digoxin prevents heart ischemia–reperfusion injury through a REV-ERBα–UPS signaling pathway. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00148-z (2022).
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Digoxin chronotherapy can modulate myocardial ischemia–reperfusion injury. Nat Cardiovasc Res 1, 988–989 (2022). https://doi.org/10.1038/s44161-022-00173-y
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DOI: https://doi.org/10.1038/s44161-022-00173-y
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