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Angiogenesis

VEGF-C and VE-cadherin: balancing sinusoidal and lymphatic angiogenesis

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From Nature Cardiovascular Research

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Sinusoidal vessels are specialized vascular structures required for hematopoiesis. A new study demonstrates a role for VEGF-C–VEGFR3 signaling in the development of sinusoidal vessels and a previously unappreciated reciprocal regulatory relationship between VE-cadherin and VEGFR3.

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Fig. 1: VEGF-C and VE-cadherin reciprocally regulate endothelial control of hematopoiesis and lymphatic development.

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Authors and Affiliations

  1. Cell and Molecular Biology Program, Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA

    Timothy J. McCord

  2. Cardiovascular Research Center, Duke University Medical Center, Durham, NC, USA

    Timothy J. McCord & Christopher D. Kontos

  3. Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA

    Christopher D. Kontos

Authors
  1. Timothy J. McCord
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  2. Christopher D. Kontos
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Correspondence to Christopher D. Kontos.

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The authors have no conflicts of interest.

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McCord, T.J., Kontos, C.D. VEGF-C and VE-cadherin: balancing sinusoidal and lymphatic angiogenesis. Nat Cardiovasc Res 1, 976–977 (2022). https://doi.org/10.1038/s44161-022-00164-z

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