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Genome-wide association studies

Prioritizing treatments for stroke through human genetics

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From Nature Cardiovascular Research

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A recent study by the GIGASTROKE consortium combines genetic discovery, fine-mapping and proteomic data to identify causal genes and variants related to disease. Results reveal known and new targets for prevention or treatment of stroke, and highlight the importance of genomics for drug discovery and development.

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Fig. 1: Venn diagram of 20 genes identified in the genomics-driven drug discovery analysis supported by several lines of genetic evidence.

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Acknowledgements

D.K. is supported by the Department of Veterans Affairs Office of Research Development, IK2 BX 005759-01.

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Authors and Affiliations

  1. VA Palo Alto Healthcare System, Palo Alto, California, USA

    Derek Klarin

  2. Department of Surgery, Stanford University School of Medicine, Stanford, California, USA

    Derek Klarin

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  1. Derek Klarin
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Correspondence to Derek Klarin.

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Competing interests

D.K. is a scientific advisor and reports consulting fees from Bitterroot Bio, unrelated to the present work.

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Klarin, D. Prioritizing treatments for stroke through human genetics. Nat Cardiovasc Res 1, 876–877 (2022). https://doi.org/10.1038/s44161-022-00132-7

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