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Fixing a current problem in the cardiac Na channel

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Dysregulation of voltage-gated cardiac Na channels can be arrhythmogenic. A new study shows that splice variants of fibroblast growth factor homologous factors (FHFs) can either promote or suppress arrhythmogenic late Na current, and the peptide inhibitor FixR could represent a therapeutic strategy to treat cardiac arrhythmias.

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Fig. 1: INa,L is increased in pathological conditions, prolonging the duration of cardiac action potentials, and different FHFs can tune INa,L.

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Authors and Affiliations

  1. Department of Pharmacology, University of California, Davis, CA, USA

    Bence Hegyi & Donald M. Bers

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  1. Bence Hegyi
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  2. Donald M. Bers
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Correspondence to Donald M. Bers.

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The authors declare no competing interests.

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Hegyi, B., Bers, D.M. Fixing a current problem in the cardiac Na channel. Nat Cardiovasc Res 1, 408–409 (2022). https://doi.org/10.1038/s44161-022-00070-4

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