d-cyclodextrins are naturally occurring macrocyclic oligosaccharides that act as hosts for hydrophobic guests and are produced on a multi-tonne scale. Now, using chemical synthesis, mirror-image cyclodextrins are produced from l- instead of d-glucose units.
This is a preview of subscription content, log in via an institution to check access.
References
Young, B. E., Kundu, N. & Sczepanski, J. T. Chem. Eur. J. 34, 7981–7990 (2019).
Lander, A. J., Jin, Y. & Luk, L. Y. P. Chembiochem 24, e202200537 (2023).
Boulineau, F. P. & Wei, A. J. Org. Chem. 69, 3391–3399 (2004).
Del Valle, E. M. M. Process Biochem. 39, 1033–1176 (2004).
Rekharsky, M. V. & Inoue, Y. Chem. Rev. 98, 1875–1917 (1998).
Ikatu, D. et al. Science 364, 674–677 (2019).
Nakagawa, T., Ueno, K., Kashiwa, M. & Watanabe, J. Tetrahedron Lett. 35, 1921–1924 (1994).
Wakao, M., Fukase, K. & Kusumoto, S. J. Org. Chem. 67, 8182–8190 (2002).
Erichsen, A., Peters, G. H. & Beeren, S. R. J. Am. Chem. Soc. 145, 4882–4891 (2023).
Wu, Y. et al. Nat. Synth. https://doi.org/10.1038/s44160-024-00495-8 (2024).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Beeren, S.R. Synthesis of l-cyclodextrins. Nat. Synth (2024). https://doi.org/10.1038/s44160-024-00512-w
Published:
DOI: https://doi.org/10.1038/s44160-024-00512-w
- Springer Nature Limited