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Asymmetric catalysis

Making α-aryl quaternary stereocentres

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Palladium-catalysed enantioselective α-arylation of azlactones and 5H-oxazol-4-ones with aryl halides using Sadphos ligands enables the synthesis of α-aryl quaternary amino acids and glycolic acid derivatives.

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Fig. 1: Palladium-catalysed asymmetric α-arylation of azlactones and 5H-oxazol-4-ones using Sadphos ligands.

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Authors and Affiliations

  1. Department of Chemistry, Federal University of Juiz de Fora, Juiz de Fora, Brazil

    Juliana Alves dos Santos & Giovanni Wilson Amarante

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  1. Juliana Alves dos Santos
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  2. Giovanni Wilson Amarante
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Correspondence to Giovanni Wilson Amarante.

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dos Santos, J.A., Amarante, G.W. Making α-aryl quaternary stereocentres. Nat. Synth 3, 293–295 (2024). https://doi.org/10.1038/s44160-023-00445-w

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