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Prebiotic nucleosides

Tides over titanium

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Making ribonucleosides from ribose and nucleobases was the first prebiotic route to be suggested, but it is challenging to achieve with high selectivity and efficiency. Now, wet–dry cycles over acidified titanium minerals in water restore a traditional approach as the most atom-economical and sustainable method.

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Fig. 1: Regioselective synthesis of ribonucleosides from the corresponding nucleobase and ribose under ‘prebiotic’ conditions.

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  1. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR 5246, CNRS, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France

    Peter Strazewski

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  1. Peter Strazewski
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Correspondence to Peter Strazewski.

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Strazewski, P. Tides over titanium. Nat. Synth 2, 315–316 (2023). https://doi.org/10.1038/s44160-023-00255-0

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