Skip to main content
SpringerLink
Log in

Isotopic labelling

Triple 13C-labelling via hydroformylation

  • News & Views
  • Published:

From Nature Synthesis

View current issue Submit your manuscript

Preparing molecules with multiple 13C labels is difficult owing to the lack of available 13C-labelled reagents. Now, a hydroformylation approach to the synthesis of [13C3]propionaldehyde, using gas surrogates, provides a straightforward method to prepare bioactive molecules with three 13C labels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: A gas surrogate approach to prepare [13C3]propionaldehyde via hydroformylation and subsequent applications in isotopic labelling.

References

  1. Elmore, C. S. & Bragg, R. A. Bioorg. Med. Chem. Lett. 25, 167–171 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Atzrodt, J., Derdau, V., Kerr, W. J. & Reid, M. Angew. Chem. Int. Ed. 57, 1758–1784 (2018).

    Article  CAS  Google Scholar 

  3. Derdau, V., Atzrodt, J., Zimmermann, J., Kroll, C. & Brückner, F. Chem. Eur. J. 15, 10397–10404 (2009).

    Article  CAS  PubMed  Google Scholar 

  4. Krauser, J. A. J. Labelled Comp. Radiopharm. 56, 441–446 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. Hammershøj, H. C. D. et al. Nat. Synth. https://doi.org/10.1038/s44160-022-00223-0 (2023).

    Article  Google Scholar 

  6. Franke, R., Selent, D. & Börner, A. Chem. Rev. 112, 5675–5732 (2012).

    Article  CAS  PubMed  Google Scholar 

  7. Friis, S. D., Lindhardt, A. T. & Skrydstrup, T. Acc. Chem. Res. 49, 594–605 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Seiche, W., Schuschkowski, A. & Breit, B. Adv. Synth. Catal. 347, 1488–1494 (2005).

    Article  CAS  Google Scholar 

  9. Hollmann, D., Bähn, S., Tillack, A. & Beller, M. Chem. Commun. 3199–3201 (2008).

  10. Babin, V., Taran, F. & Audisio, D. JACS Au 2, 1234–1251 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

  1. Twitter: @Doylem3535

Authors and Affiliations

  1. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

    Michael G. J. Doyle & Rylan J. Lundgren

Authors
  1. Michael G. J. Doyle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rylan J. Lundgren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rylan J. Lundgren.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Doyle, M.G.J., Lundgren, R.J. Triple 13C-labelling via hydroformylation. Nat. Synth 2, 205–206 (2023). https://doi.org/10.1038/s44160-022-00229-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44160-022-00229-8

  • Springer Nature Limited

Search

Navigation