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Synthetic methodology

Copper for alkynylallylic substitution

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Chiral tetrahedral carbon atoms bearing functional groups amenable to functionalization offer numerous synthetic opportunities. Catalysed by copper pyridine-bis(oxazoline) complexes, the developed alkynylallylic substitution provides 3-substituted 1,4-enynes with excellent regio- and stereocontrol.

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Fig. 1: Enantioselective alkynylallylic substitution.

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  1. Van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Jan H. van Maarseveen

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  1. Jan H. van Maarseveen
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Correspondence to Jan H. van Maarseveen.

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van Maarseveen, J.H. Copper for alkynylallylic substitution. Nat. Synth 2, 11–12 (2023). https://doi.org/10.1038/s44160-022-00192-4

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