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Antibiotics the easy way

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Aminoglycosides are an important class of potent antibiotics; however traditional synthetic approaches are lengthy and often rely on enzyme-based routes. Now, a formal enantioselective copper-catalysed hydroamination of benzene enables the total synthesis of the antibiotic (+)-ribostamycin in ten linear steps.

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Fig. 1: Copper-catalysed enantioselective hydroamination of benzene for the synthesis of the antibiotic (+)-ribostamycin.

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Authors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, TX, USA

    Danniel K. Arriaga & Andy A. Thomas

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  1. Danniel K. Arriaga
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  2. Andy A. Thomas
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Correspondence to Andy A. Thomas.

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Arriaga, D.K., Thomas, A.A. Antibiotics the easy way. Nat. Synth 1, 504–505 (2022). https://doi.org/10.1038/s44160-022-00093-6

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