The nature of biological networks still brings challenges related to computational complexity, interpretable results and statistical significance. Recent work proposes a new method that paves the way for addressing these issues when analyzing cancer genomic data.
References
Yang, L., Chen, R., Goodison, S. & Yijun, S. Nat. Comput. Sci. https://doi.org/10.1038/s43588-020-00009-4 (2021).
Stratton, M. R., Campbell, P. J. & Futreal, P. A. Nature 458, 719–724 (2009).
International Cancer Genome Consortium. Nature 464, 993–998 (2010).
Garraway, L. A. & Lander, E. S. Cell 153, 17–37 (2013).
Licata, L. et al. Nucleic Acids Res. 48, D504–D510 (2020).
Türei, D., Korcsmáros, T. & Saez-Rodriguez, J. Nat. Methods 13, 966–967 (2016).
Signorelli, M., Vinciotti, V. & Wit, E. C. BMC Bioinform. 17, 352 (2016).
Ciriello, G., Cerami, E., Sander, C. & Schultz, N. Genome Res. 22, 398–406 (2012).
Mathews, J. C. et al. Proc. Natl Acad. Sci. USA 117, 16339–16345 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
F.I. receives funding from Open Targets, a public–private initiative involving academia and industry and performs consultancy for the joint CRUK–AstraZeneca Functional Genomics Centre. All the other authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Najgebauer, H., Perron, U. & Iorio, F. Redefining false discoveries in cancer data analyses. Nat Comput Sci 1, 22–23 (2021). https://doi.org/10.1038/s43588-020-00008-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43588-020-00008-5
- Springer Nature America, Inc.