Our analysis of the spatiotemporal transcriptional features of human ovarian aging at the single-cell level identified the DNA damage response as a fundamental attribute in oocyte senescence. FOXP1, a gatekeeper both in granulosa and in theca and stroma cellular senescence, can be activated by quercetin treatment to delay ovarian aging.
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This is a summary of: Wu, M. et al. Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. Nat. Aging https://doi.org/10.1038/s43587-024-00607-1 (2024).
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FOXP1 is a gatekeeper of cellular senescence with ovarian aging. Nat Aging 4, 451–452 (2024). https://doi.org/10.1038/s43587-024-00608-0
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DOI: https://doi.org/10.1038/s43587-024-00608-0
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