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Partial reprogramming

Partial reprogramming of the mammalian brain

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Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a neurogenic niche that is defined, in part, by restoration of neuroblast levels.

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Fig. 1: Partial OSKM reprogramming reverts aged SVZ cell composition toward a more youthful state.

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Acknowledgements

N.C.A. is supported by a Postdoctoral Training Program for Research on Aging Grant T32 AG049672. Research in the laboratory of M.J.S. is supported by grants from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA

    Niels C. Asmussen & Marissa J. Schafer

  2. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA

    Niels C. Asmussen & Marissa J. Schafer

  3. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    Marissa J. Schafer

Authors
  1. Niels C. Asmussen
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  2. Marissa J. Schafer
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Correspondence to Marissa J. Schafer.

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The authors declare no competing interests.

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Asmussen, N.C., Schafer, M.J. Partial reprogramming of the mammalian brain. Nat Aging 4, 440–442 (2024). https://doi.org/10.1038/s43587-024-00596-1

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