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Epigenetic clocks

Epigenetic clock work ticks forward

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Ying et al. integrate Mendelian randomization into epigenetic clock making and pioneer a strategy to develop aging biomarkers with stronger causal ties to healthspan. They distinguish signs of aging-related molecular damage from responses to it that might signal resilience.

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Fig. 1: Typology of age-associated CpG sites revealed by Mendelian randomization analysis of healthspan and longevity.

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Acknowledgements

D.W.B. is a fellow of the CIFAR CBD Network.

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Authors and Affiliations

  1. Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA

    C. P. Ryan & D. W. Belsky

  2. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA

    D. W. Belsky

Authors
  1. C. P. Ryan
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  2. D. W. Belsky
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Correspondence to D. W. Belsky.

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Competing interests

D.W.B. is listed as an inventor of the Duke University and University of Otago invention DunedinPACE, which is licensed to TruDiagnostic. C.P.R. declares no competing interests.

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Ryan, C.P., Belsky, D.W. Epigenetic clock work ticks forward. Nat Aging 4, 170–172 (2024). https://doi.org/10.1038/s43587-024-00570-x

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