Skip to main content
SpringerLink
Log in

Epigenetics of aging

Slow and steady lives the longest

  • News & Views
  • Published:

From Nature Aging

View current issue Submit your manuscript

Two recent studies discover a scaling law of mammalian lifespans: the speed at which DNA methylation drifts from a youthful state strongly associates with maximum lifespan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: The rate at which DNA methylation drifts from a youthful state scales with lifespan.

References

  1. West, G. B. & Brown, J. H. J. Exp. Biol. 208, 1575–1592 (2005).

    Article  PubMed  Google Scholar 

  2. Crofts, S. J. C., Latorre-Crespo, E. & Chandra, T. Nat. Aging https://doi.org/10.1038/s43587-023-00535-6 (2023).

    Article  PubMed  Google Scholar 

  3. Horvath, S., Zhang, J., Haghani, A. & Fei, Z. Preprint at bioRxiv, https://doi.org/10.1101/2023.05.21.541643 (2023).

  4. Booth, L. N. & Brunet, A. Mol. Cell 62, 728–744 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hannum, G. et al. Mol. Cell 49, 359–367 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Horvath, S. Genome Biol. 14, 3156 (2013).

    Article  Google Scholar 

  7. Lu, A. T. et al. Nat. Aging 3, 1144–1166 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lowe, R. et al. Genome Biol. 19, 22 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wilkinson, G. S. et al. Nat. Commun. 12, 1615 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bertucci-Richter, E. M. & Parrott, B. B. Nat. Commun. 14, 7731 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cagan, A. et al. Nature 604, 517–524 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Moqri, M. et al. Preprint at bioRxiv, https://doi.org/10.1101/2022.06.03.494609 (2022).

  13. Rakyan, V. K. et al. Genome Res. 20, 434–439 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Tian, X. et al. Cell 177, 622–638.e22 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Research in the authors’ laboratories is supported by grants from the US National Institutes on Aging (A.S. and V.G.), the Milky Way Foundation, Michael Antonov Foundation, Impetus grant (V.G.).

Author information

Authors and Affiliations

  1. Department of Biology, University of Rochester, Rochester, NY, USA

    Francesco Morandini, Andrei Seluanov & Vera Gorbunova

  2. Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA

    Andrei Seluanov & Vera Gorbunova

Authors
  1. Francesco Morandini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrei Seluanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vera Gorbunova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vera Gorbunova.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morandini, F., Seluanov, A. & Gorbunova, V. Slow and steady lives the longest. Nat Aging 4, 7–9 (2024). https://doi.org/10.1038/s43587-023-00554-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-023-00554-3

  • Springer Nature America, Inc.

Search

Navigation