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Longevity

Early exposure to a systemic stressor confers protection later in life

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Oleson et al. tackle the enduring question of the extent to which transient events during development shape our outcomes by studying the effects of early-life exposure to oxidative stress. They find that a cascade of changes initiated by the epigenetic-modifier COMPASS complex manifests in rearrangements in lipid metabolism in adulthood, which confers broad protection against amyloid-induced proteotoxicity.

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Fig. 1: Early-life exposure to ROS protects from amyloid-induced toxicity later in life.

References

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Acknowledgements

S.S. is supported in part by research grants to S.S. from the NIH/NIDDK (R01 DK124706) and NIH/NIA (R01 AG056648).

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Authors and Affiliations

  1. Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA

    Supriya Srinivasan

  2. Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA

    Supriya Srinivasan

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  1. Supriya Srinivasan
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Correspondence to Supriya Srinivasan.

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Srinivasan, S. Early exposure to a systemic stressor confers protection later in life. Nat Aging 4, 10–11 (2024). https://doi.org/10.1038/s43587-023-00553-4

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