Epigenome deregulation is considered a hallmark of aging; however, the function of the alteration of DNA methylation in aged tissues is a long-standing question. Hong and colleagues reveal the mechanism and consequences of DNA methylation loss at heterochromatin regions in aged hematopoietic stem cells.
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Acknowledgements
This work was supported by the Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 2021 ID 26038).
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Krepelova, A., Neri, F. DNA methylation controls hematopoietic stem cell aging. Nat Aging 3, 1320–1322 (2023). https://doi.org/10.1038/s43587-023-00511-0
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DOI: https://doi.org/10.1038/s43587-023-00511-0
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