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Leveraging the secretory machinery to eliminate senescent cells

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Senescent cells accumulate with age and promote tissue decline. A broad genomic screen reveals that senescent cells can be eliminated from aged mice by interfering with their unique secretory program. Reducing the capacity of the endoplasmic reticulum by inhibiting the YAP–TEAD complex sensitizes senescent cells to apoptosis.

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Fig. 1: YAP–TEAD inhibition triggers lethal endoplasmic reticulum stress in senescent cells, ameliorating senescence-related fibrosis in aged mice.

References

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This is a summary of: Anerillas, C. et al. The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nat. Aging https://doi.org/10.1038/s43587-023-00480-4 (2023).

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Leveraging the secretory machinery to eliminate senescent cells. Nat Aging 3, 1183–1184 (2023). https://doi.org/10.1038/s43587-023-00500-3

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  • DOI: https://doi.org/10.1038/s43587-023-00500-3

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