Cost-effective and scalable means for detecting amyloid-β positivity in clinical practice are urgently needed. Here, in three memory clinic cohorts, we show that risk stratification with a plasma p-tau217-based model can substantially reduce the need for expensive or invasive testing, while still accurately determining the amyloid-β status of patients with cognitive impairment.
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This is a summary of: Brum, W. S. et al. A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases. Nat. Aging, https://doi.org/10.1038/s43587-023-00471-5 (2023).
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Cost-effective Alzheimer’s disease detection using plasma p-tau217-based risk stratification. Nat Aging 3, 1053–1054 (2023). https://doi.org/10.1038/s43587-023-00485-z
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DOI: https://doi.org/10.1038/s43587-023-00485-z
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