Lysosomes are small vesicles in which cellular constituents are enzymatically degraded. Villalobos and colleagues now show that in Caenorhabditis elegans a shift in lysosome morphology from a vesicular to a tubular shape is critical for the lifespan extension triggered by calorie restriction. Moreover, tubular lysosomes form even in well-fed descendants of calorically restricted parents for up to four generations.
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Acknowledgements
T.V. was supported by the grant OTKA (Hungarian Scientific Research Fund; K132439) and ELKH-ELTE (Eötvös Loránd Research Network-Eötvös Loránd University) Genetics Research Group (01062).
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Sigmond, T., Vellai, T. Lysosomal alteration links food limitation to longevity. Nat Aging 3, 1048–1050 (2023). https://doi.org/10.1038/s43587-023-00483-1
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DOI: https://doi.org/10.1038/s43587-023-00483-1
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