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Intestinal aging

Deteriorating maintenance of the intestinal wall

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Intestinal barrier dysfunction is a hallmark of aging. Zhang and colleagues examine the replenishment of adherens junctions in the intestine of aged Caenorhabditis elegans and discover the role of the SDPN-1–RAB-10 axis in the dysregulated endocytic recycling, offering new insights into the age-dependent impairment of the intestinal barrier.

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Fig. 1: Deteriorating maintenance of the intestinal barrier during aging.

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Authors and Affiliations

  1. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China

    Yifan Chen & Yidong Shen

  2. University of Chinese Academy of Sciences, Beijing, China

    Yifan Chen & Yidong Shen

Authors
  1. Yifan Chen
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  2. Yidong Shen
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Correspondence to Yidong Shen.

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The authors declare no competing interests.

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Chen, Y., Shen, Y. Deteriorating maintenance of the intestinal wall. Nat Aging 3, 1046–1047 (2023). https://doi.org/10.1038/s43587-023-00477-z

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