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Neurodegeneration

LONRF2 is a gatekeeper against protein aggregation in aging neurons

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Neuronal aging is highly associated with misfolded protein aggregates that predispose to neurodegeneration, but the cellular factors that are involved in removing misfolded proteins are yet to be identified. In this issue of Nature Aging, Li and colleagues identified LONRF2 as an important player in protecting aging neurons against the accumulation of protein aggregates.

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Fig. 1: LONRF2 protects aging neurons from the accumulation of misfolded proteins.

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Authors and Affiliations

  1. Genetics and Genome Biology Program, The Hospital for Sick Children (SickKids) Research Institute, Toronto, Ontario, Canada

    Mohieldin M. M. Youssef & Jeehye Park

  2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    Jeehye Park

Authors
  1. Mohieldin M. M. Youssef
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  2. Jeehye Park
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Correspondence to Jeehye Park.

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The authors declare no competing interests.

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Youssef, M.M.M., Park, J. LONRF2 is a gatekeeper against protein aggregation in aging neurons. Nat Aging 3, 913–914 (2023). https://doi.org/10.1038/s43587-023-00457-3

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  • DOI: https://doi.org/10.1038/s43587-023-00457-3

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